The green chemistry employs the raw materials from biomass and renewable energy producing minimal wastes. The name green itself concerns about the production of highly specialized materials and bioactive compounds more structurally complex than the compounds prepared by conventional methods. These high added value molecules with a short life span, a high profit margin and made especially for the consumers require the development of new synthetic approaches. Non-thermal Activation Methods is related to all works related to microwaves, plasma, ultrasound, electrochemistry, photochemistry, mechanochemistry, etc. The techniques developed in chemical and pharmaceutical industries concerns about the chemical product design and manufacturing. Many activation techniques such as ultrasound, microwaves, and photocatalysis are being part of the green methodologies used for the synthesis of high added value molecules.