The concept of green chemistry upholds a special position for bioprocesses. Processes we design and operate must have minimal potential environmental impacts while optimised for maximum benefits. Few steps for greener bioprocesses include design processes that bypass toxic solvent use; design milder process and multiple product recovery routes; bypassing the chemical equilibrium with innovative designs, and bio-catalysis. The recent developments of bioprocesses integrating natural or tailor-made biocatalysts for biomass conversion into valuable compounds. It also targets the concept of synthetic pathways constituting both chemical and bio-catalytic transformations to produce bio-sourced derivatives.